Saturday, April 20, 2024

As I was saying...

The RNA World

More recently, some have claimed that another scenario-the RNA world hypothesis, combining chance and prebiotic natural selection can solve the origin-of-life problem and with it, presumably, the problem of the origin of genetic information. The RNA world was proposed as an explanation for the origin of the interdependence of DNA and proteins in the cell's information-processing system. In extant cells, building proteins requires genetic information stored in DNA, but information in DNA cannot be processed without many specific proteins and protein complexes. This poses a chicken-or-egg problem.


(Okay Call it what you want lol.

Trying to find work-arounds

around the truth?

Simply never works.)


"The discovery that RNA a nucleic acid that contains genetic information) also possesses some limited catalytic properties similar to those of proteins suggested a way to solve that problem. "RNA-first" advocates proposed an early state in which RNA performed both the enzymatic functions of modern proteins and the information-storage function of modern DNA, thus allegedly making the interdependence of DNA and proteins unnecessary in the earliest living systems. They also envision primitive self-copying RNA molecules, or "RNA replicators," that can produce molecular off-spring capable of competing for survival and, thus, inducing a process of prebiotic natural selection."

Nevertheless, many fundamental difficulties with the RNA-world scenario have emerged. First, synthesizing (or maintaining) many essential building blocks of RNA molecules under realistic conditions has proven either difficult or impossible." Second, naturally occurring RNA possesses very few of the specific enzymatic properties of proteins necessary to extant cells. Indeed, RNA catalysts do not function as true enzyme catalysts. For instance, many enzymes are capable of coupling energetically favorable and energetically unfavorable reactions together (ie, reactions that otherwise would not proceed spontaneously), RNA catalysts, so-called ribozymes, are not capable of doing this."


"Third, attempts to enhance the limited catalytic properties of RNA molecules in "ribozyme-engineering" experiments have inevitably required extensive investigator manipulation, thus simulating, if anything. the need for intelligent design. Fourth, RNA-world advocates offer no plausible explanation for how primitive RNA replicators might have evolved into modern cells that rely almost exclusively on proteins to process and translate genetic information and regulate metabolism."


Most important, the RNA-world hypothesis presupposes, but does not explain, the origin of sequence specificity or information in the original functional RNA replicators. To date, scientists have been able to design RNA catalysts that will copy only about 10 percent of themselves." For strands of RNA to perform even this limited self-replication function, they must have very specific arrangements of their constituent nucleotide building blocks. Further, the strands must be long enough to fold into complex three-dimensional shapes (so-called tertiary structures). Thus, any RNA molecule capable of even limited function must have possessed considerable specified information content. Yet explaining how the building blocks of RNA arranged themselves into functionally specified sequences has proven no easier than explaining how the constituent parts of DNA might have done so. As de Duve noted in a critique of the RNA-world hypothesis

"Hitching the components together 

in the right manner 

raises additional problems 

of such magnitude 

that no one has yet attempted to do so 

in a prebiotic context."


Translation?

The more complex the sequences?

The less likely it is due to chance.

As one goes up?

(complex sequences)

The other goes down

(Chance)

and it does so exponentially.


So no wonder that:

"...no one has yet attempted 

to do so in a prebiotic context."


One more thing to point out:

From the post:

"Here"


From the article:

RNA's hidden potential: 

New study unveils its role in early life and future bioengineering


"For this, they designed an artificial ribozyme," 


"We modified the structure by adding specific domains that can interact with various effectors."


"the researchers altered the structure of the R3C ligase."


"Furthermore, engineered ribozymes such as the one developed in this study."



"Third, attempts to enhance the limited catalytic properties of RNA molecules in "ribozyme-engineering" experiments have inevitably required extensive investigator manipulation, thus simulating, if anything. the need for intelligent design."

 Pages 180-181.


Ill sum it up for ya real simple:


"Were gonna play God in the lab 

to prove to you there isn't one."


1 Corinthians 3:19

For the wisdom of this world 

is foolishness with God. 

For it is written, 

He taketh the wise 

in their own craftiness.


(He makes them look like fools)


I can hear them already Lucy:

"Well you just read a book 

blah blah blah..."


First of all?

"A"?

As in singular?



Omgoodness Lucy they are just killing me.


Yeah, reading a book was how I was able to survive living in a garage for two years,

(Not to mention a whole list of other things miles long at this point) 

Knowing what God had promised me/us

for my/our future(s) couldn't have possibly had anything to do with it.

Makes perfect sense.

Explains everything.

People please.


Hebrews 11 7-8

FAITH IN ACTION

(Subheading for Hebrews11)

BY FAITH Noah, when warned about things not yet seen, in holy fear built an ark to save his family. By his faith he condemned the world and became heir of the righteousness that is in keeping with faith.


BY FAITH Abraham, when called to go to a place he would later receive as his inheritance, obeyed and went, even though he did not know where he was going. 


(Resonates! More than a lot!)


One day people gonna figure out 

my arguments aren't my arguments.

I just hope it isn't to late for your soul.


I got this thing I do called:

NEXT!

(As in next argument.)



Keep setting them up.

The almighty is just gonna keep knocking them down.

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